The future of NMR-based metabolomics

The two leading analytical approaches to metabolomics are mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Although currently overshadowed by MS in terms of numbers of compounds resolved, NMR spectroscopy offers advantages both on its own and coupled with MS. NMR data are highly reproducible and quantitative over a wide dynamic range and are unmatched for determining structures of unknowns. NMR is adept at tracing metabolic pathways and fluxes using isotope labels. Moreover, NMR is non-destructive and can be utilized in vivo. NMR results have a proven track record of translating in vitro findings to in vivo clinical applications.

• GC
  Genome Canada
• NI
  National Institutes of Health

  Awards: R01GM085291, DK097209-01A1, P41GM103399, P30CA015704, R01 GM 066041, P20 RR-17675, R01GM109046, P30GM103335, R01 AI087668-01A1, P41GM111135, R01 CA163649-01A1