reviewCold Spring Harbor Perspectives in MedicineSep 6, 2016HYBRID OA

HDACs and HDAC Inhibitors in Cancer Development and Therapy

YLYixuan LiESEdward Seto

George Washington University

Indexed incrossref

Abstract

Over the last several decades, it has become clear that epigenetic abnormalities may be one of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play a crucial role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear architecture. Histone acetylation, a well-studied posttranslational histone modification, is controlled by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). By removing acetyl groups, HDACs reverse chromatin acetylation and alter transcription of oncogenes and tumor suppressor genes. In addition, HDACs deacetylate numerous nonhistone cellular substrates that…

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Topics & keywords

Topics
Keywords
  • Cancer therapy
  • Cancer
  • Cancer research
  • Medicine
  • Oncology
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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