articleCancer ResearchAug 16, 2016GREEN OA

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

ALAlan L. ChangJMJason MiskaDADerek A. WainwrightMDMahua DeyCVClaudia V. Rivetta

Northwestern University · University of Chicago · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by local immunosuppression driven by the accumulation of regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC). However, the mechanistic details of how Tregs and MDSCs are recruited in various tumors are not yet well understood. Here we report that macrophages and microglia within the glioma microenvironment produce CCL2, a chemokine that is critical for recruiting both CCR4+ Treg and CCR2+Ly-6C+ monocytic MDSCs in this disease setting. In murine gliomas, we established novel roles for tumor-derived CCL20 and osteoprotegerin in inducing CCL2 production from macrophages and microglia. Tumors grown in…

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611
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Authors

16

Topics & keywords

Topics
Keywords
  • Microglia
  • Tumor microenvironment
  • CCR2
  • Glioma
  • Cancer research
  • Myeloid-derived Suppressor Cell
  • CCL2
  • Chemokine
UN Sustainable Development Goals
  • Good health and well-being
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