Organic Reactions in Microdroplets: Reaction Acceleration Revealed by Mass Spectrometry

The striking finding that reaction acceleration occurs in confined-volume solutions sets up an apparent conundrum: Microdroplets formed by spray ionization can be used to monitor the course of bulk-phase reactions and also to accelerate reactions between the reagents in such a reaction. This Minireview introduces droplet and thin-film acceleration phenomena and summarizes recent methods applied to study accelerated reactions in confined-volume, high-surface-area solutions. Conditions that dictate either simple monitoring or acceleration are reconciled in the occurrence of discontinuous and complete desolvation as the endpoint of droplet evolution. The contrasting features of microdroplet and bulk-solution…

• UD
  U.S. Department of Defense
• UD
  U.S. Department of Energy

  Award: DE-FG02-06ER15807
• DA
  Defense Advanced Research Projects Agency

  Award: W911NF-16-2-0020
• BE
  Basic Energy Sciences
• GT
  Geothermal Technologies Office

  Award: DE-FG02-06ER15807