PRODIGY: a web server for predicting the binding affinity of protein–protein complexes
University of Applied Sciences Utrecht · Utrecht University · +2 more institutions
Abstract
Gaining insights into the structural determinants of protein-protein interactions holds the key for a deeper understanding of biological functions, diseases and development of therapeutics. An important aspect of this is the ability to accurately predict the binding strength for a given protein-protein complex. Here we present PROtein binDIng enerGY prediction (PRODIGY), a web server to predict the binding affinity of protein-protein complexes from their 3D structure. The PRODIGY server implements our simple but highly effective predictive model based on intermolecular contacts and properties derived from non-interface surface. AVAILABILITY AND IMPLEMENTATION: PRODIGY is freely available at:…
Citation impact
- FWCI
- 15.14
- Percentile
- 100%
- References
- 18
Authors
5- LCLi C. XueCorresponding
University of Applied Sciences Utrecht, Utrecht University, Stanford University
- JPJoão Pglm Rodrigues
University of Applied Sciences Utrecht, Utrecht University
- PLPanagiotis L. Kastritis
University of Applied Sciences Utrecht, Utrecht University, European Molecular Biology Laboratory
- AMAlexandre M. J. J. Bonvin
University of Applied Sciences Utrecht, Utrecht University
- AVAnna Vangone
University of Applied Sciences Utrecht, Utrecht University
Topics & keywords
- Web server
- Computer science
- Interface (matter)
- Protein–protein interaction
- Binding protein
- Computational biology
- Chemistry
- Biology
- Affordable and clean energy