The CXCL8-CXCR1/2 pathways in cancer
Tongji Hospital · Huazhong University of Science and Technology · +3 more institutions
Abstract
Persistent infection or chronic inflammation contributes significantly to tumourigenesis and tumour progression. C-X-C motif ligand 8 (CXCL8) is a chemokine that acts as an important multifunctional cytokine to modulate tumour proliferation, invasion and migration in an autocrine or paracrine manner. Studies have suggested that CXCL8 and its cognate receptors, C-X-C chemokine receptor 1 (CXCR1) and C-X-C chemokine receptor 2 (CXCR2), mediate the initiation and development of various cancers including breast cancer, prostate cancer, lung cancer, colorectal carcinoma and melanoma. CXCL8 also integrates with multiple intracellular signalling pathways to produce coordinated effects. Neovascularisation, which…
Citation impact
- FWCI
- 19.02
- Percentile
- 100%
- References
- 177
Authors
9- QLQian Liu
Tongji Hospital, Huazhong University of Science and Technology
- ALAnping Li
First Affiliated Hospital of Zhengzhou University
- YTYijun Tian
Tongji Hospital, Huazhong University of Science and Technology
- JDJennifer D. Wu
MUSC Hollings Cancer Center, Medical University of South Carolina
- YLYu Liu
Tongji Hospital, Huazhong University of Science and Technology
Topics & keywords
- Autocrine signalling
- CXC chemokine receptors
- Cancer research
- Paracrine signalling
- Chemokine
- Interleukin 8
- Chemokine receptor
- Metastasis
- Good health and well-being