Alpha‐synuclein  RT ‐Qu IC  in the  CSF  of patients with alpha‐synucleinopathies

Fairfoul, Graham; McGuire, Lynne I.; Pal, Suvankar; Ironside, James W.; Neumann, Juliane; Christie, Sharon; Joachim, Catherine; Esiri, Margaret M.; Evetts, Samuel; Rolinski, Michal; Baig, Fahd; Ruffmann, Claudio; Wade‐Martins, Richard; Hu, Michele T. M.; Parkkinen, Laura; Green, Alison J. E.

doi:10.1002/acn3.338

articleAnnals of Clinical and Translational NeurologyAug 28, 2016GOLD OA

Alpha‐synuclein RT ‐Qu IC in the CSF of patients with alpha‐synucleinopathies

GFGraham Fairfoul LILynne I. McGuire SPSuvankar Pal JWJames W. Ironside JNJuliane Neumann

Western General Hospital · University of Edinburgh · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful…

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Topics & keywords

Topics

Keywords

Synucleinopathies
Medicine
Alpha (finance)
Alpha-synuclein
Internal medicine
Parkinson's disease
Disease

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