Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure
Hospital Clínic de Barcelona · Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · +28 more institutions
Abstract
Acute‐on‐chronic liver failure (ACLF) in cirrhosis is characterized by acute decompensation (AD), organ failure(s), and high short‐term mortality. Recently, we have proposed (systemic inflammation [SI] hypothesis) that ACLF is the expression of an acute exacerbation of the SI already present in decompensated cirrhosis. This study was aimed at testing this hypothesis and included 522 patients with decompensated cirrhosis (237 with ACLF) and 40 healthy subjects. SI was assessed by measuring 29 cytokines and the redox state of circulating albumin (HNA2), a marker of systemic oxidative stress. Systemic circulatory dysfunction (SCD) was estimated by plasma renin (PRC) and copeptin (PCC) concentrations. Measurements…
Citation impact
- FWCI
- 31.01
- Percentile
- 100%
- References
- 39
Authors
28- JCJoan Clària
Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- RSRudolf Stauber
Medical University of Graz
- MJMinneke J. Coenraad
Leiden University Medical Center
- RMRichard Moreau
Inserm, Délégation Paris 7, Université Paris Cité, Hôpital Beaujon, Sorbonne Paris Cité, Assistance Publique – Hôpitaux de Paris, Centre de Recherche sur l'Inflammation
- RJRajiv Jalan
The Royal Free Hospital, University College London
Topics & keywords
- Cirrhosis
- Medicine
- Inflammation
- Liver failure
- Systemic inflammation
- Internal medicine
- Gastroenterology
- Good health and well-being