Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the antibodies inhibiting the PD-1/PD-L1 axis, are among the most promising immunotherapies for patients with advanced colon cancer, but their durable response rate remains low. We herein report the use of immunogenic nanoparticles to augment the antitumour efficacy of PD-L1 antibody-mediated cancer immunotherapy. Nanoscale coordination polymer (NCP) core-shell nanoparticles carry oxaliplatin in the core and the photosensitizer pyropheophorbide-lipid conjugate (pyrolipid) in the shell (NCP@pyrolipid) for effective chemotherapy and…

• UO
  University of Chicago

  Awards: P30 CA014599, CA014599
• NI
  National Institutes of Health

  Awards: P30 CA014599, CA014599
• UO
  University of Chicago Medicine
• NC
  National Cancer Institute

  Awards: CA198989, CA014599, P30 CA014599, U01-CA198989
• CC
  Comprehensive Cancer Center, University of Chicago Medical Center

  Awards: NIH CCSG: P30 CA014599, P30 CA014599