Integration of omic networks in a developmental atlas of maize

Coexpression networks and gene regulatory networks (GRNs) are emerging as important tools for predicting functional roles of individual genes at a system-wide scale. To enable network reconstructions, we built a large-scale gene expression atlas composed of 62,547 messenger RNAs (mRNAs), 17,862 nonmodified proteins, and 6227 phosphoproteins harboring 31,595 phosphorylation sites quantified across maize development. Networks in which nodes are genes connected on the basis of highly correlated expression patterns of mRNAs were very different from networks that were based on coexpression of proteins. Roughly 85% of highly interconnected hubs were not conserved in expression between RNA and protein networks.…

• NS
  National Science Foundation

  Awards: MCB1122246, MCB-0929402, 924023
• HH
  Howard Hughes Medical Institute
• GA
  Gordon and Betty Moore Foundation

  Award: GBMF3034