On the Stability of BOLD fMRI Correlations
Washington University in St. Louis · The University of Texas at Dallas · +4 more institutions
Abstract
Measurement of correlations between brain regions (functional connectivity) using blood oxygen level dependent (BOLD) fMRI has proven to be a powerful tool for studying the functional organization of the brain. Recently, dynamic functional connectivity has emerged as a major topic in the resting-state BOLD fMRI literature. Here, using simulations and multiple sets of empirical observations, we confirm that imposed task states can alter the correlation structure of BOLD activity. However, we find that observations of "dynamic" BOLD correlations during the resting state are largely explained by sampling variability. Beyond sampling variability, the largest part of observed "dynamics" during rest is attributable…
Citation impact
- FWCI
- 41.86
- Percentile
- 100%
- References
- 95
Authors
16- TOTimothy O. LaumannCorresponding
Washington University in St. Louis
- AZAbraham Z. Snyder
Washington University in St. Louis
- AMAnish Mitra
Washington University in St. Louis
- EMEvan M. Gordon
The University of Texas at Dallas, VA Heart of Texas Health Care Network, Center for Occupational Research and Development
- CGCaterina Gratton
Washington University in St. Louis
Topics & keywords
- Dynamic functional connectivity
- Resting state fMRI
- Functional connectivity
- Correlation
- Blood-oxygen-level dependent
- Neuroscience
- Functional magnetic resonance imaging
- Stability (learning theory)