Antibiotics as deep modulators of gut microbiota: between good and evil

The recent increase in our knowledge of human gut microbiota has changed our view on antibiotics. Antibiotics are, indeed, no longer considered only beneficial, but also potentially harmful drugs, as their abuse appears to play a role in the pathogenesis of several disorders associated with microbiota impairment (eg, Clostridium difficile infection or metabolic disorders). Both drug-related factors (such as antibiotic class, timing of exposure or route of administration) and host-related factors appear to influence the alterations of human gut microbiota produced by antibiotics. Nevertheless, antibiotics are nowadays considered a reliable therapy for some non-communicable disorders, including IBS or hepatic…

• BF
  Bundesministerium für Wissenschaft, Forschung und Wirtschaft
• ÖF
  Österreichische Forschungsförderungsgesellschaft

  Awards: 843536, K-Project Nr. 843536
• BF
  Bundesministerium für Verkehr, Innovation und Technologie
• ST
  Standortagentur Tirol
• WW
  Wirtschaftsagentur Wien