Copper(II)–Graphitic Carbon Nitride Triggered Synergy: Improved ROS Generation and Reduced Glutathione Levels for Enhanced Photodynamic Therapy
Changchun Institute of Applied Chemistry · University of Chinese Academy of Sciences
Abstract
Graphitic carbon nitride (g-C3 N4 ) has been used as photosensitizer to generate reactive oxygen species (ROS) for photodynamic therapy (PDT). However, its therapeutic efficiency was far from satisfactory. One of the major obstacles was the overexpression of glutathione (GSH) in cancer cells, which could diminish the amount of generated ROS before their arrival at the target site. Herein, we report that the integration of Cu(2+) and g-C3 N4 nanosheets (Cu(2+) -g-C3 N4 ) led to enhanced light-triggered ROS generation as well as the depletion of intracellular GSH levels. Consequently, the ROS generated under light irradiation could be consumed less by reduced GSH, and efficiency was improved. Importantly,…
Citation impact
- FWCI
- 22.40
- Percentile
- 100%
- References
- 33
Authors
10- EJEnguo Ju
Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- KDKai Dong
Changchun Institute of Applied Chemistry
- ZCZhaowei Chen
Changchun Institute of Applied Chemistry
- ZLZhen Liu
Changchun Institute of Applied Chemistry
- CLChaoqun Liu
University of Chinese Academy of Sciences
Topics & keywords
- Photodynamic therapy
- Graphitic carbon nitride
- Glutathione
- Copper
- Nitride
- Chemistry
- Materials science
- Nanotechnology