High-throughput discovery of novel developmental phenotypes

Dickinson, Mary E.; Flenniken, Ann M.; Ji, Xiao; Teboul, Lydia; Wong, Michael D.; White, Jacqueline K.; Meehan, Terrence F.; Weninger, Wolfgang J.; Westerberg, Henrik; Adissu, Hibret A.; Baker, Candice N.; Bower, Lynette; Brown, James M.; Caddle, L. Brianna; Chiani, Francesco; Clary, Dave; Cleak, James; Daly, Mark J.; Denegre, James M.; Doe, Brendan; Dolan, M. Eileen; Edie, Sarah; Fuchs, Helmut; Gailus-Durner, Valerie; Galli, Antonella; Gambadoro, Alessia; Gallegos, Juan; Guo, Shiying; Horner, Neil; Hsu, Chih‐Wei; Johnson, Sara; Kalaga, Sowmya; Keith, Lance C.; Lanoue, Louise; Lawson, Thomas N.; Lek, Monkol; Mark, Manuel; Marschall, Susan; Mason, Jeremy; McElwee, Melissa L.; Newbigging, Susan; Nutter, Lauryl M. J.; Peterson, Kevin A.; Ramírez‐Solis, Ramiro; Rowland, Douglas J.; Ryder, Edward J.; Samocha, Kaitlin E.; Seavitt, John R.; Selloum, Mohammed; Szoke-Kovacs, Zsombor; Tamura, Masaru; Trainor, Amanda; Tudose, Ilinca; Wakana, Shigeharu; Warren, Jonathan; Wendling, Olivia; West, David B.; Wong, Leeyean; Yoshiki, Atsushi; Wurst, Wolfgang; MacArthur, Daniel G.; Tocchini‐Valentini, Glauco P.; Gao, Xiang; Flicek, Paul; Bradley, Allan; Skarnes, William C.; Justice, Monica J.; Parkinson, Helen; Moore, Mark W.; Wells, Sara; Braun, Robert E.; Svenson, Karen L.; Angelis, Martin Hrabě de; Hérault, Yann; Mohun, Tim; Mallon, Ann‐Marie; Henkelman, R. Mark; Brown, Steve D. M.; Adams, David J.; Lloyd, K. C. Kent; McKerlie, Colin; Beaudet, Arthur L.; Bućan, Maja; Murray, Stephen A.

doi:10.1038/nature19356

articleNatureSep 13, 2016GREEN OA

High-throughput discovery of novel developmental phenotypes

MEMary E. Dickinson AMAnn M. Flenniken XJXiao Ji LTLydia Teboul MDMichael D. Wong

Radiation Biophysics Laboratory · Mount Sinai Hospital · +29 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

No abstract available for this paper.

Citation impact

1,290

total citations

FWCI: 162.72
Percentile: 100%
References: 64

Citations per year

Authors

ME
Mary E. DickinsonCorresponding
Radiation Biophysics Laboratory
AM
Ann M. Flenniken
Mount Sinai Hospital, Toronto Centre for Phenogenomics
XJ
Xiao Ji
University of Pennsylvania
LT
Lydia Teboul
Medical Research Council, Mary Lyon Centre at MRC Harwell
MD
Michael D. Wong
Hospital for Sick Children, Toronto Centre for Phenogenomics

Topics & keywords

Topics

Cell Image Analysis Techniques100%
Molecular Biology Techniques and Applications100%
Single-cell and spatial transcriptomics100%

Keywords

Gene knockout
Biology
Phenotype
Genetics
Gene
Gene targeting
Penetrance
Computational biology

UN Sustainable Development Goals

Partnerships for the goals

No related works found for this paper.

Funding

GC
Genome Canada
Award: OGI-051
WT
Wellcome Trust
OG
Ontario Genomics
Award: OGI-051
I
INFRAFRONTIER
Award: 01KX1012
GO
Government of Canada
AN
Agence Nationale de la Recherche
Awards: ANR-10-IDEX-, ANR-10-INBS-07, ANR-10-IDEX-0002, ANR-10-IDEX, ANR-10-INBS-07 PHENOMIN, 10-IDEX-0002-02, ANR-10, ANR-10-IDEX-0002-02
IN
Institut National de la Santé et de la Recherche Médicale
Awards: ANR-10-INBS-07 PHENOMIN, ANR-10-IDEX-0002-02, ANR-10-IDEX-0002, ANR-10-INBS-07
BF
Bundesministerium für Bildung und Forschung
Award: 01KX1012
UD
Université de Strasbourg
Awards: ANR-10-IDEX-0002-02, ANR-10-IDEX-0002
CN
Centre National de la Recherche Scientifique
Awards: ANR-10-IDEX-0002-02, ANR-10-IDEX-0002
P
PHENOMIN
Award: ANR-10-INBS-07
NI
National Institutes of Health
Awards: U42 OD011185, HG006348, U54 HG006348, HG006332, U54 HG006332, U54 HG006370, OD011175, U42 OD011175
MR
Medical Research Council