Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
University of Minnesota · Arizona State University
Abstract
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuronal structure and function. Although these receptors share common signaling pathways, they are capable of having distinct effects on cellular plasticity. We investigated the individual effects of mGluR1a or mGluR5 activation on dendritic spine density in medium spiny neurons in the nucleus accumbens (NAc), which has become relevant with the potential use of group I mGluR based therapeutics in the treatment of drug addiction. We found that systemic administration of mGluR subtype-specific positive allosteric modulators had opposite effects on dendritic spine densities. Specifically, mGluR5 positive modulation…
Citation impact
- FWCI
- 72.71
- Percentile
- 100%
- References
- 36
Authors
6Topics & keywords
- Dendritic spine
- Medium spiny neuron
- Metabotropic glutamate receptor
- Nucleus accumbens
- Metabotropic glutamate receptor 5
- Striatum
- SPINE (molecular biology)
- Glutamate receptor
- Good health and well-being