articleNano LettersSep 13, 2016Closed access

Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies

XSXuejiao SongLFLiangzhu FengCLChao LiangKYKai YangZLZhuang Liu

Soochow University

PubMed
Indexed incrossrefpubmed

Abstract

Tumor hypoxia is known to be one of critical reasons that limit the efficacy of cancer therapies, particularly photodynamic therapy (PDT) and radiotherapy (RT) in which oxygen is needed in the process of cancer cell destruction. Herein, taking advantages of the great biocompatibility and high oxygen dissolving ability of perfluorocarbon (PFC), we develop an innovative strategy to modulate the tumor hypoxic microenvironment using nano-PFC as an oxygen shuttle for ultrasound triggered tumor-specific delivery of oxygen. In our experiment, nanodroplets of PFC stabilized by albumin are intravenously injected into tumor-bearing mice under hyperoxic breathing. With a low-power clinically adapted ultrasound transducer…

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Topics & keywords

Topics
Keywords
  • Tumor hypoxia
  • Hypoxia (environmental)
  • Tumor microenvironment
  • Photodynamic therapy
  • Oxygenation
  • Medicine
  • Cancer
  • Lung cancer
UN Sustainable Development Goals
  • Good health and well-being
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