Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute myeloid leukemia (AML); however, the best approach to maximize NK cell antileukemia potential is unclear. Cytokine-induced memory-like NK cells differentiate after a brief preactivation with interleukin-12 (IL-12), IL-15, and IL-18 and exhibit enhanced responses to cytokine or activating receptor restimulation for weeks to months after preactivation. We hypothesized that memory-like NK cells exhibit enhanced antileukemia functionality. We demonstrated that human memory-like NK cells have enhanced interferon-γ production and cytotoxicity against leukemia cell lines or primary human AML blasts in vitro. Using mass cytometry,…

• HH
  Howard Hughes Medical Institute
• CC
  Conquer Cancer Foundation
• VF
  V Foundation for Cancer Research
• AS
  American Society of Hematology
• GA
  Gabrielle's Angel Foundation for Cancer Research
• NC
  National Cancer Institute

  Award: F32 CA200253