Clinical significance of tumor-infiltrating lymphocytes in breast cancer

Tumor infiltrating lymphocytes (TIL) play an essential role in mediating response to chemotherapy and improving clinical outcomes in all subtypes of breast cancer. Triple negative breast cancers (TN) are most likely to have tumors with >50 % lymphocytic infiltrate, termed lymphocyte predominant breast cancer, and derive the greatest survival benefit from each 10 % increase in TIL. The majority of HER2 + breast cancers have similar level of immune infiltrate as TN breast cancer yet the presence of TILs has not shown the same survival benefit. For HER2 + breast cancers, type 1 T-cells, either increased TBET + tumor infiltration or increased type 1 HER2-specific CD4 + T-cells in the peripheral blood, are…

• UD
  U.S. Department of Defense

  Awards: W81XWH-11-1-, W81XWH, W81XWH-11-1-0760
• UO
  University of Washington
• NI
  National Institutes of Health

  Awards: KL2TR000421, W81XWH