A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, Michael; VanderSluis, Benjamin; Koch, Elizabeth N.; Baryshnikova, Anastasia; Pons, Carles; Tan, Guihong; Wang, Wen; Ušaj, Matej; Hanchard, Julia; Lee, Susan D.; Pelechano, Vicent; Styles, Erin B.; Billmann, Maximilian; Leeuwen, Jolanda van; Dyk, Nydia van; Lin, Zhen-Yuan; Kuzmin, Elena; Nelson, Justin; Piotrowski, Jeff S.; Srikumar, Tharan; Bahr, Sondra; Chen, Yiqun; Deshpande, Raamesh; Kurat, Christoph F.; Li, Sheena C.; Li, Zhijian; Ušaj, Mojca Mattiazzi; Okada, Hiroki; Pascoe, Natasha; Luis, Bryan-Joseph San; Sharifpoor, Sara; Shuteriqi, Emira; Simpkins, Scott W.; Snider, Jamie; Suresh, Harsha Garadi; Tan, Yizhao; Zhu, Hongwei; Malod‐Dognin, Noël; Janjić, Vuk; Pržulj, Nataša; Troyanskaya, Olga G.; Štagljar, Igor; Xia, Tian; Ohya, Yoshikazu; Gingras, Anne‐Claude; Raught, Brian; Boutros, Michael; Steinmetz, Lars M.; Moore, Claire; Rosebrock, Adam P.; Caudy, Amy A.; Myers, Chad L.; Andrews, Brenda; Boone, Charles

doi:10.1126/science.aaf1420

articleScienceSep 22, 2016GREEN OA

A global genetic interaction network maps a wiring diagram of cellular function

MCMichael Costanzo BVBenjamin VanderSluis ENElizabeth N. Koch ABAnastasia Baryshnikova CPCarles Pons

University of Toronto · University of Minnesota · +18 more institutions

PubMed

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Abstract

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic interaction occurs when two mutations, neither lethal individually, combine to cause cell death. Conversely, positive genetic interactions occur when two mutations produce a phenotype that is less severe than expected. Genetic interactions identify functional relationships between genes and can be harnessed for biological discovery and therapeutic target identification. They may also explain a considerable component of the undiscovered genetics associated with human diseases. Here, we describe construction and analysis of a comprehensive…

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Keywords

Diagram
Function (biology)
Computer science
Biology
Evolutionary biology
Database

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