The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and…

• NS
  National Science Foundation

  Awards: 1153911, BCS-1032255, 0924726, 02543, 1032255
• WT
  Wellcome Trust

  Award: 098051
• SF
  Simons Foundation Autism Research Initiative
• EC
  European Commission

  Awards: 15,16, 261213, 28,29
• RF
  Russian Foundation for Basic Research

  Awards: 16-06-00364, 16-06-00303
• ET
  Eesti Teadusagentuur

  Awards: IUT24, IUT24-1
• M
  Max-Planck-Gesellschaft
• V
  Vetenskapsrådet

  Awards: 16,17, 02543, 2014-453
• TÜ
  Tartu Ülikool
• NI
  National Institutes of Health

  Awards: 1R01GM113657, R01-GM094402, 16,17, 1R01DK104339-01, GM59290, 1R01DK104339, 1R01GM113657-01, 10,11, GM100233, 5DP1ES022577 05
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/H008802/1, BB/H008802/2
• ER
  European Regional Development Fund

  Award: IUT24-1