reviewCirculation Cardiovascular GeneticsSep 21, 2016DIAMOND OA

Epigenetic Signatures of Cigarette Smoking

RJRoby JoehanesACAllan C. JustRERiccardo E. MarioniLCLuke C. PillingLMLindsay M. Reynolds

Lindsay Unified School District · Tân Tạo University · +21 more institutions

PubMed
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Abstract

Background— DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, lung, and cardiovascular disorders. Methods and Results— To comprehensively determine the association between cigarette smoking and DNA methylation, we conducted a meta-analysis of genome-wide DNA methylation assessed using the Illumina BeadChip 450K array on 15 907 blood-derived DNA samples from participants in 16 cohorts (including 2433 current, 6518 former, and 6956 never smokers). Comparing current versus never smokers, 2623 cytosine–phosphate–guanine sites (CpGs), annotated to 1405 genes, were…

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1,020
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Authors

83

Topics & keywords

Topics
Keywords
  • Epigenetics
  • DNA methylation
  • Biology
  • Genetics
  • Cigarette smoking
  • Medicine
  • Bioinformatics
  • Computational biology
UN Sustainable Development Goals
  • Good health and well-being
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