Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
Johns Hopkins University · Johns Hopkins Medicine · +7 more institutions
Abstract
INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, cognitive impairment. Pathologically, PD is characterized by the accumulation of α-synuclein in Lewy bodies and neurites. There is degeneration of neurons throughout the nervous system, with the degeneration of dopamine neurons in the substantia nigra pars compacta leading to the major symptoms of PD. RATIONALE In the brains of PD patients, pathologic α-synuclein seems to spread from cell to cell via self-amplification, propagation, and transmission in a stereotypical and topographical pattern among neighboring cells and/or anatomically…
Citation impact
- FWCI
- 49.99
- Percentile
- 100%
- References
- 53
Authors
32- XMXiaobo Mao
Johns Hopkins University, Johns Hopkins Medicine
- MTMichael T. Ou
Johns Hopkins University, Johns Hopkins Medicine
- SSSenthilkumar S. Karuppagounder
Johns Hopkins University, Johns Hopkins Medicine
- TKTae‐In Kam
Johns Hopkins University, Johns Hopkins Medicine
- XYXiling Yin
Johns Hopkins University, Johns Hopkins Medicine
Topics & keywords
- Substantia nigra
- Pars compacta
- Alpha-synuclein
- Biology
- Cell biology
- Neuroscience
- Lewy body
- Parkinson's disease