Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions
University of Cambridge · University College London · +2 more institutions
Abstract
Inflammatory cytokines are commonly elevated in acute depression and are associated with resistance to monoaminergic treatment. To examine the potential role of cytokines in the pathogenesis and treatment of depression, we carried out a systematic review and meta-analysis of antidepressant activity of anti-cytokine treatment using clinical trials of chronic inflammatory conditions where depressive symptoms were measured as a secondary outcome. Systematic search of the PubMed, EMBASE, PsycINFO and Cochrane databases, search of reference lists and conference abstracts, followed by study selection process yielded 20 clinical trials. Random effect meta-analysis of seven randomised controlled trials (RCTs)…
Citation impact
- FWCI
- 15.80
- Percentile
- 100%
- References
- 76
Authors
5- NKNils KappelmannCorresponding
University of Cambridge
- GLGlyn Lewis
University College London
- RDRobert Dantzer
The University of Texas MD Anderson Cancer Center
- PBPeter B. Jones
University of Cambridge, Cambridgeshire and Peterborough NHS Foundation Trust
- GMGolam M. Khandaker
University of Cambridge, Cambridgeshire and Peterborough NHS Foundation Trust
Topics & keywords
- Medicine
- Internal medicine
- Meta-analysis
- Placebo
- Antidepressant
- Etanercept
- Depression (economics)
- Adalimumab
- Good health and well-being
Funding
- UOUniversity of Rochester
- RPRegeneron Pharmaceuticals
- WTWellcome TrustAwards: 088869/Z/09/Z, 201486/Z/16/Z, 095844/Z/11/Z, 095844
- NINational Institute for Health and Care ResearchAward: RP-PG-0606-1335
- AOAcademy of Medical SciencesAward: 80354
- UUUmeå Universitet
- UDUniversidade de São Paulo
- UPUniversité Pierre et Marie Curie
- NINational Institutes of HealthAwards: R01 NS073939, R01 NS074999, NS074999
- NCNIHR Cambridge Biomedical Research Centre