Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good…

• CU
  City University of Hong Kong

  Awards: CityU 11301215, 11301215
• NN
  National Natural Science Foundation of China

  Awards: KQTD2015032416270385, 51372175, 11301215, 61435010
• SN
  SLAC National Accelerator Laboratory