The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · Istituti di Ricovero e Cura a Carattere Scientifico · +3 more institutions
Abstract
Despite clear evidence that exosomal microRNAs (miRNAs) are able to modulate the cellular microenvironment and that exosomal RNA cargo selection is deregulated in pathological conditions, the mechanisms controlling specific RNA sorting into extracellular vesicles are still poorly understood. Here, we identified the RNA binding protein SYNCRIP (synaptotagmin-binding cytoplasmic RNA-interacting protein; also known as hnRNP-Q or NSAP1) as a component of the hepatocyte exosomal miRNA sorting machinery. SYNCRIP knockdown impairs sorting of miRNAs in exosomes. Furthermore, SYNCRIP directly binds to specific miRNAs enriched in exosomes sharing a common extra-seed sequence (hEXO motif). The hEXO motif has a role in…
Citation impact
- FWCI
- 23.85
- Percentile
- 100%
- References
- 49
Authors
10- LSLaura Santangelo
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Pasteur, Sapienza University of Rome
- GGGiorgio Giurato
University of Salerno
- CCCarla Cicchini
Istituto Pasteur, Sapienza University of Rome
- CMClaudia Montaldo
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Istituti di Ricovero e Cura a Carattere Scientifico
- CMCarmine Mancone
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Pasteur, Sapienza University of Rome
Topics & keywords
- Microvesicles
- microRNA
- Cell biology
- Biology
- RNA
- Exosome
- RNA-binding protein
- Gene knockdown