Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human disease variants are enriched for polymorphisms that affect gene expression, including some that are known to associate with expression changes in the brain. Postulating that many variants confer risk to neurodegenerative disease via transcriptional regulatory mechanisms, we have analyzed gene expression levels in the brain tissue of subjects with AD and related diseases. Herein, we describe our collective datasets comprised of GWAS data from 2,099 subjects; microarray gene expression data from 773 brain…

• MJ
  Michael J. Fox Foundation for Parkinson's Research

  Awards: U24 NS072026, 05-901, 211002, P30 AG19610
• MC
  Mayo Clinic

  Awards: 05-901, U24 NS072026, U01 AG046139, P30 AG19610, P50 AG016574, R01 AG032990, U01 AG006786, R01 NS080820, 211002
• MF
  Mayo Foundation for Medical Education and Research

  Award: AG016574
• AD
  Arizona Department of Health Services

  Awards: P30 AG19610, P50 AG016574, U24 NS072026, 05-901, 211002, R01 AG032990
• C
  CurePSP
• GF
  GHR Foundation
• AB
  Arizona Biomedical Research Commission

  Awards: P30 AG19610, 05-901, contracts 4001, 0011, 05-901 and 1001, U24 NS072026, 4001, 0011, 05-901 and 1001, 211002
• NI
  National Institute on Aging

  Awards: 211002, R01 AG032990, R01 AG003949, U24 NS072026, AG046139, R01 AG017216, R01 AG018023, U01 AG046139, AG016574, U01 AG006576, U01 AG006786, P50 AG016574, R01 AG025711, AG025711, 05-901, AG19610, P30 AG19610, AG006786, AG017216, AG003949
• NI
  National Institute of Neurological Disorders and Stroke

  Awards: R01 NS080820, P50 AG016574, U24 NS072026, NS072026, 211002, NS080820, 05-901, U24 NS072026 National Brain, P30 AG19610