Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

Neutrophils, the most abundant type of leukocytes in blood, can form neutrophil extracellular traps (NETs). These are pathogen-trapping structures generated by expulsion of the neutrophil's DNA with associated proteolytic enzymes. NETs produced by infection can promote cancer metastasis. We show that metastatic breast cancer cells can induce neutrophils to form metastasis-supporting NETs in the absence of infection. Using intravital imaging, we observed NET-like structures around metastatic 4T1 cancer cells that had reached the lungs of mice. We also found NETs in clinical samples of triple-negative human breast cancer. The formation of NETs stimulated the invasion and migration of breast cancer cells in…

• UD
  U.S. Department of Defense

  Award: W81XWH-14-1-0078
• CR
  Cancer Research Institute
• AF
  Aid for Cancer Research
• JG
  Joni Gladowsky Breast Cancer Foundation
• HF
  Hope Foundation
• BI
  Boehringer Ingelheim Fonds
• DF
  Deutsche Forschungsgemeinschaft

  Award: KU 3264/1-1
• NI
  National Institutes of Health

  Award: 5U01CA180944-02
• NC
  National Cancer Institute

  Award: K99 CA181490