The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Centre National de la Recherche Scientifique · Pennsylvania State University · +7 more institutions
Abstract
Adrenal glucocorticoids are major modulators of multiple functions, including energy metabolism, stress responses, immunity, and cognition. The endogenous secretion of glucocorticoids is normally characterized by a prominent and robust circadian (around 24 hours) oscillation, with a daily peak around the time of the habitual sleep-wake transition and minimal levels in the evening and early part of the night. It has long been recognized that this 24-hour rhythm partly reflects the activity of a master circadian pacemaker located in the suprachiasmatic nucleus of the hypothalamus. In the past decade, secondary circadian clocks based on the same molecular machinery as the central master pacemaker were found in…
Citation impact
- FWCI
- 13.97
- Percentile
- 100%
- References
- 458
Authors
9- HOHenrik OsterCorresponding
Centre National de la Recherche Scientifique, Pennsylvania State University, Leiden University Medical Center, University of Surrey, University of Bristol, University of Chicago, University of Turin, Université de Strasbourg, University of Lübeck
- ÉCÉtienne Challet
Centre National de la Recherche Scientifique, Pennsylvania State University, Leiden University Medical Center, University of Surrey, University of Bristol, University of Chicago, University of Turin, Université de Strasbourg, University of Lübeck
- VOVolker Ott
Centre National de la Recherche Scientifique, Pennsylvania State University, Leiden University Medical Center, University of Surrey, University of Bristol, University of Chicago, University of Turin, Université de Strasbourg, University of Lübeck
- EAEmanuela Arvat
Centre National de la Recherche Scientifique, Pennsylvania State University, Leiden University Medical Center, University of Surrey, University of Bristol, University of Chicago, University of Turin, Université de Strasbourg, University of Lübeck
- ERE. R. de Kloet
Centre National de la Recherche Scientifique, Pennsylvania State University, Leiden University Medical Center, University of Surrey, University of Bristol, University of Chicago, University of Turin, Université de Strasbourg, University of Lübeck
Topics & keywords
- Circadian rhythm
- Suprachiasmatic nucleus
- Light effects on circadian rhythm
- Endocrinology
- Biology
- Internal medicine
- Hypothalamus
- Neuroscience
- Good health and well-being