articleProceedings of the National Academy of SciencesOct 18, 2016BRONZE OA

Situating the default-mode network along a principal gradient of macroscale cortical organization

DSDaniel S. MarguliesSGSatrajit GhoshAGAlexandros GoulasMFMarcel FalkiewiczJMJulia M. Huntenburg

Max Planck Institute for Human Cognitive and Brain Sciences · Harvard University · +13 more institutions

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Abstract

Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions…

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2,598
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100%
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Authors

12

Topics & keywords

Topics
Keywords
  • Default mode network
  • Principal (computer security)
  • Mode (computer interface)
  • Functional connectivity
  • Neuroscience
  • Computer science
  • Psychology
  • Computer security
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