articleJCI InsightOct 19, 2016GOLD OA

The head and neck cancer immune landscape and its immunotherapeutic implications

RMRajarsi MandalYŞYasin ŞenbabaoğluADAlexis DesrichardJJJonathan J. HavelMGMartin G. Dalin

Swim Across America · Memorial Sloan Kettering Cancer Center

PubMed
Indexed incrossrefdoajpubmed

Abstract

Recent clinical trials have demonstrated a clear survival advantage in advanced head and neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade. These emerging results reveal that HNSCC is one of the most promising frontiers for immunotherapy research. However, further progress in head and neck immuno-oncology will require a detailed understanding of the immune infiltrative landscape found in these tumors. We leveraged transcriptome data from 280 tumors profiled by The Cancer Genome Atlas (TCGA) to comprehensively characterize the immune landscape of HNSCC in order to develop a rationale for immunotherapeutic strategies in HNSCC and guide clinical investigation. We find that both…

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Topics & keywords

Topics
Keywords
  • TIGIT
  • Head and neck squamous-cell carcinoma
  • Immune system
  • Immunotherapy
  • Cancer research
  • Immune checkpoint
  • Medicine
  • Head and neck cancer
UN Sustainable Development Goals
  • Good health and well-being
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