P1‐146: Chlamydia Pneumoniae‐ Infected Astrocytes Alter Their Expression of Adam10, Bace1, and Presenilin‐1 Proteases

Utilizing β-amyloid precursor protein (βAPP) as a substrate, α-, β-, and γ-secretases are responsible for sequential cleavage events leading to the formation of β-amyloid, the classic pathologic hallmark of Alzheimer’s Disease. Members of this class of proteases also catalyze the activation of numerous other membrane-localized proteins implicated in cell growth and neuroinflammation such as NOTCH and the Interleukin/TNF-receptor family, respectively. This investigation addresses if an in vitro Chlamydia pneumoniae infection of human astrocytes affects the processing of βAPP through modifying the protein expression of the following βAPP processing proteases: A Disintegrin and Metalloproteinase-10 (ADAM10), βAPP…