Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
National Cancer Institute · Center for Cancer Research · +2 more institutions
Indexed incrossrefpubmed
Abstract
Poly(ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism of action by PARP "trapping" and what this means for both clinical monotherapy and combination with chemotherapeutic agents.
Citation impact
754
total citations
- FWCI
- 27.04
- Percentile
- 100%
- References
- 79
Citations per year
Authors
3Topics & keywords
Topics
Keywords
- Trap (plumbing)
- Cancer cell
- Poly ADP ribose polymerase
- Action (physics)
- Cancer research
- Chemistry
- Cancer
- Pharmacology
UN Sustainable Development Goals
- Good health and well-being
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