Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging
University of Oklahoma Health Sciences Center · University of Pecs · +1 more institution
Abstract
Increasing evidence from epidemiological, clinical and experimental studies indicate that age-related cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) are expected to have a major role in preserving brain health in older individuals. Maintenance of cerebral perfusion, protecting the microcirculation from high pressure-induced damage and moment-to-moment adjustment of regional oxygen and nutrient supply to changes in demand are…
Citation impact
- FWCI
- 27.70
- Percentile
- 100%
- References
- 316
Authors
4- PTPéter Tóth
University of Oklahoma Health Sciences Center, University of Pecs
- STStefano Tarantini
University of Oklahoma Health Sciences Center
- ACAnna Csiszár
University of Szeged, University of Oklahoma Health Sciences Center
- ZUZoltán UngváriCorresponding
University of Szeged, University of Oklahoma Health Sciences Center
Topics & keywords
- Cerebral blood flow
- Dementia
- Neuroscience
- Medicine
- Ischemia
- Cerebral perfusion pressure
- Cerebral autoregulation
- Neuroinflammation
- Good health and well-being
Funding
- AHAmerican Heart Association
- OCOklahoma Center for the Advancement of Science and Technology
- MTMagyar Tudományos AkadémiaAward: BO/00634/15
- NINational Institute on AgingAwards: R01-AG038747, R01-AG047879
- NCNational Center for Complementary and Alternative MedicineAward: R01-AT006526
- NINational Institute of Neurological Disorders and StrokeAward: R01-NS056218