A transcription factor hierarchy defines an environmental stress response network
Salk Institute for Biological Studies · Carnegie Mellon University
Abstract
Environmental stresses are universally encountered by microbes, plants, and animals. Yet systematic studies of stress-responsive transcription factor (TF) networks in multicellular organisms have been limited. The phytohormone abscisic acid (ABA) influences the expression of thousands of genes, allowing us to characterize complex stress-responsive regulatory networks. Using chromatin immunoprecipitation sequencing, we identified genome-wide targets of 21 ABA-related TFs to construct a comprehensive regulatory network in Arabidopsis thaliana Determinants of dynamic TF binding and a hierarchy among TFs were defined, illuminating the relationship between differential gene expression patterns and ABA pathway…
Citation impact
- FWCI
- 89.43
- Percentile
- 100%
- References
- 98
Authors
10Topics & keywords
- Abscisic acid
- Transcription factor
- Arabidopsis
- Biology
- Multicellular organism
- Gene regulatory network
- Arabidopsis thaliana
- Computational biology