Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident macrophages, with unique transcriptional profiles endowing the cells with tissue-specific functions. However, it is unknown whether the origins of different macrophage populations affect their roles in malignancy. Given potential artifacts associated with irradiation-based lineage tracing, it remains unclear if bone-marrow-derived macrophages (BMDMs) are present in tumors of the brain, a tissue with no homeostatic involvement of BMDMs. Here, we employed multiple models of murine brain malignancy and genetic lineage tracing to demonstrate that BMDMs are abundant in primary and metastatic brain tumors. Our data indicate that…

• AB
  American Brain Tumor Association
• MS
  Memorial Sloan-Kettering Cancer Center

  Award: CA008748
• LI
  Ludwig Institute for Cancer Research

  Award: R01CA181355
• DF
  Deutsche Forschungsgemeinschaft

  Awards: SE2234/1-1, KL 2491/1-1, P30 CA008748
• CI
  Canadian Institutes of Health Research
• NC
  National Cancer Institute

  Awards: R01CA181355, 5F31CA167863, CA008748, P30 CA008748