Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial
Kashan University of Medical Sciences
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Abstract
Alzheimer's disease (AD) is associated with severe cognitive impairments as well as some metabolic defects. Scant studies in animal models indicate a link between probiotics and cognitive function. This randomized, double-blind and controlled clinical trial was conducted among 60 AD patients to assess the effects of probiotic supplementation on cognitive function and metabolic status. The patients were randomly divided into two groups (n=30 in each group) treating with either milk (control group) or a mixture of probiotic (probiotic group). The probiotic supplemented group took 200 ml/day probiotic milk containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum and Lactobacillus…
Citation impact
909
total citations
- FWCI
- 29.64
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- 100%
- References
- 65
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Authors
8Topics & keywords
Keywords
- Bifidobacterium bifidum
- Lactobacillus fermentum
- Probiotic
- Lactobacillus acidophilus
- Internal medicine
- Medicine
- Quantitative insulin sensitivity check index
- Lactobacillus casei
UN Sustainable Development Goals
- Good health and well-being
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