Functionalized Nano-MoS 2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
Chinese Academy of Sciences · Institute of High Energy Physics · +4 more institutions
Abstract
We have developed a biocompatible antibacterial system based on polyethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS2 NFs). The PEG-MoS2 NFs have high near-infrared (NIR) absorption and peroxidase-like activity, which can efficiently catalyze decomposition of low concentration of H2O2 to generate hydroxyl radicals (·OH). The conversion of H2O2 into ·OH can avoid the toxicity of high concentration of H2O2 and the ·OH has higher antibacterial activity, making resistant bacteria more vulnerable and wounds more easily cured. The PEG-MoS2 NFs combine the catalysis with NIR photothermal effect, providing a rapid and effective killing outcome in vitro for Gram-negative ampicillin resistant…
Citation impact
- FWCI
- 33.25
- Percentile
- 100%
- References
- 58
Authors
7- WYWenyan YinCorresponding
Chinese Academy of Sciences, Institute of High Energy Physics
- JYJie Yu
Northwestern Polytechnical University, Chinese Academy of Sciences, Institute of High Energy Physics
- FLFengting Lv
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry
- LYLiang Yan
Chinese Academy of Sciences, Institute of High Energy Physics
- LZLirong Zheng
Chinese Academy of Sciences, Institute of High Energy Physics
Topics & keywords
- Photothermal therapy
- Chemistry
- Bacillus subtilis
- Catalysis
- Polyethylene glycol
- Antibacterial activity
- Combinatorial chemistry
- Nuclear chemistry
Funding
- NNNational Natural Science Foundation of ChinaAwards: 31751015, 11621505, 21320102003
- CAChinese Academy of SciencesAward: QYZDJ-SSW-SLH022
- MOMinistry of Science and Technology of the People's Republic of ChinaAwards: 2015CB932104, 2016YFA0201603, 2016YFA0202104
- NSNatural Science Foundation of Beijing MunicipalityAward: 2162046