Circadian physiology of metabolism
Salk Institute for Biological Studies · Torrey Pines Institute For Molecular Studies
Abstract
A majority of mammalian genes exhibit daily fluctuations in expression levels, making circadian expression rhythms the largest known regulatory network in normal physiology. Cell-autonomous circadian clocks interact with daily light-dark and feeding-fasting cycles to generate approximately 24-hour oscillations in the function of thousands of genes. Circadian expression of secreted molecules and signaling components transmits timing information between cells and tissues. Such intra- and intercellular daily rhythms optimize physiology both by managing energy use and by temporally segregating incompatible processes. Experimental animal models and epidemiological data indicate that chronic circadian rhythm…
Citation impact
- FWCI
- 32.08
- Percentile
- 100%
- References
- 112
Authors
1Topics & keywords
- Circadian rhythm
- Biology
- Physiology
- Bacterial circadian rhythms
- Rhythm
- Neuroscience
- Circadian clock
- Period (music)