Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles

Baron, Ralf; Maier, Christoph; Attal, Nadine; Binder, Andreas; Bouhassira, Didier; Cruccu, G.; Finnerup, Nanna Brix; Haanpää, Maija; Hansson, Per; Hüllemann, Philipp; Jensen, Troels S.; Freynhagen, Rainer; Kennedy, Jeffrey D.; Magerl, Walter; Mainka, Tina; Reimer, Maren; Rice, Andrew S.C.; Segerdahl, Märta; Serra, Jordi; Sindrup, Søren H.; Sommer, Claudia; Tölle, Thomas R.; Vollert, Jan; Treede, Rolf‐Detlef

doi:10.1097/j.pain.0000000000000753

articlePainNov 3, 2016GOLD OA

Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles

RBRalf Baron CMChristoph Maier NANadine Attal ABAndreas Binder DBDidier Bouhassira

University Hospital Schleswig-Holstein · University of Lübeck · +23 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Patients with neuropathic pain are heterogeneous in etiology, pathophysiology, and clinical appearance. They exhibit a variety of pain-related sensory symptoms and signs (sensory profile). Different sensory profiles might indicate different classes of neurobiological mechanisms, and hence subgroups with different sensory profiles might respond differently to treatment. The aim of the investigation was to identify subgroups in a large sample of patients with neuropathic pain using hypothesis-free statistical methods on the database of 3 large multinational research networks (German Research Network on Neuropathic Pain (DFNS), IMI-Europain, and Neuropain). Standardized quantitative sensory testing was used in…

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Topics & keywords

Topics

Keywords

Peripheral
Mechanism (biology)
Neuropathic pain
Sensory system
Medicine
Neuroscience
Physical medicine and rehabilitation
Psychology

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