The role of p53 in cancer drug resistance and targeted chemotherapy

// Karin Hientz 1 , André Mohr 1 , Dipita Bhakta-Guha 2 and Thomas Efferth 1 1 Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany 2 School of Chemical and Bio Technology, SASTRA University, Tamil Nadu, India Correspondence to: Thomas Efferth, email: // Keywords : cytotoxic chemotherapy, drug resistance, medicinal chemistry, prognostic factors, targeted chemotherapy Received : July 10, 2016 Accepted : October 13, 2016 Published : November 19, 2016 Abstract Cancer has long been a grievous disease complicated by innumerable players aggravating its cure. Many clinical studies demonstrated the prognostic relevance of the tumor…