Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

T cells) from up to 197 individuals. We assess, quantitatively, the relative contribution of cis-genetic and epigenetic factors to transcription and evaluate their impact as potential sources of confounding in epigenome-wide association studies. Further, we characterize highly coordinated genetic effects on gene expression, methylation, and histone variation through quantitative trait locus (QTL) mapping and allele-specific (AS) analyses. Finally, we demonstrate colocalization of molecular trait QTLs at 345 unique immune disease loci. This expansive, high-resolution atlas of multi-omics changes yields insights into cell-type-specific correlation between diverse genomic inputs, more generalizable correlations…

• MU
  McGill University
• GC
  Genome Canada
• NB
  NHS Blood and Transplant
• WT
  Wellcome Trust

  Awards: WT098051, WT091310
• EB
  European Bioinformatics Institute
• EM
  European Molecular Biology Laboratory

  Award: SEV-2012-0208
• NI
  National Institute for Health and Care Research
• BH
  British Heart Foundation

  Awards: G0800270, SP/09/002
• UO
  University of Cambridge
• UO
  University of Oxford
• MD
  Ministerio de Economía y Competitividad

  Awards: SEV-2012-0208, PT13/0001
• M
  Max-Planck-Gesellschaft
• CI
  Canadian Institutes of Health Research

  Award: EP1-120608
• MR
  Medical Research Council

  Awards: MR/L003120/1, G0800270, EU FP7
• ID
  Instituto de Salud Carlos III

  Award: PT13/0001
• NC
  NIHR Cambridge Biomedical Research Centre