GlioVis data portal for visualization and analysis of brain tumor expression datasets
Memorial Sloan Kettering Cancer Center · Spanish National Cancer Research Centre · +2 more institutions
Abstract
The effects they observed could be influenced by inhibition of other types of Trk receptors or signaling molecules downstream of Trk. We have recently started a series of experiments aiming to verify whether specific TrkB inhibition reduces glioma cell proliferation using ANA-12, a small-molecule selective TrkB antagonist. Our first results showed that ANA-12 effectively and dose-dependently reduces the viability of a human glioblastoma cell line with almost complete disappearance of cultured cells 72 hours after treatment (Fig. Therefore, selective TrkB inhibition might prove to be an effective experimental therapeutic strategy, possibly with fewer off-target toxicities compared with multitarget drugs in…
Citation impact
- FWCI
- 22.63
- Percentile
- 100%
- References
- 10
Authors
5- RLRobert L. BowmanCorresponding
Memorial Sloan Kettering Cancer Center, Spanish National Cancer Research Centre, The University of Texas MD Anderson Cancer Center, Jackson Laboratory
- QWQianghu Wang
Spanish National Cancer Research Centre, Memorial Sloan Kettering Cancer Center, The University of Texas MD Anderson Cancer Center, Jackson Laboratory
- ÁCÁngel Carro
Spanish National Cancer Research Centre, The University of Texas MD Anderson Cancer Center, Jackson Laboratory, Memorial Sloan Kettering Cancer Center
- RGRoel G.W. Verhaak
Jackson Laboratory, Spanish National Cancer Research Centre, The University of Texas MD Anderson Cancer Center, Memorial Sloan Kettering Cancer Center
- MSMassimo Squatrito
Spanish National Cancer Research Centre, Memorial Sloan Kettering Cancer Center, Jackson Laboratory, The University of Texas MD Anderson Cancer Center
Topics & keywords
- Visualization
- Computer science
- Expression (computer science)
- Data visualization
- Computational biology
- Artificial intelligence
- Information retrieval
- Biology