Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy
Chinese Academy of Sciences · Shanghai Institute of Materia Medica · +5 more institutions
Abstract
Nutrient transporters have been explored for biomimetic delivery targeting the brain. The albumin-binding proteins (e.g., SPARC and gp60) are overexpressed in many tumors for transport of albumin as an amino acid and an energy source for fast-growing cancer cells. However, their application in brain delivery has rarely been investigated. In this work, SPARC and gp60 overexpression was found on glioma and tumor vessel endothelium; therefore, such pathways were explored for use in brain-targeting biomimetic delivery. We developed a green method for blood-brain barrier (BBB)-penetrating albumin nanoparticle synthesis, with the capacity to coencapsulate different drugs and no need for cross-linkers. The…
Citation impact
- FWCI
- 20.59
- Percentile
- 100%
- References
- 36
Authors
9- TLTingting LinCorresponding
Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Tianjin Medical University, Binzhou Medical University, Binzhou University
- PZPengfei Zhao
Shanghai Institute of Materia Medica, Nanchang University, Chinese Academy of Sciences
- YJYifan Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- YTYisi Tang
Chinese Academy of Sciences, Shanghai Institute of Materia Medica
- HJHongyue Jin
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Topics & keywords
- Blood–brain barrier
- Albumin
- Drug delivery
- Drug
- Nanoparticle
- Drug carrier
- Chemistry
- Biophysics
- Good health and well-being