Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis

To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality.

Meta-analysis of prospective cohort studies. DATA SOURCES: Electronic databases (PubMed, Embase, and Google Scholar). SELECTION CRITERIA: Prospective cohort studies from general populations were included for meta-analysis if they reported adjusted relative risks with 95% confidence intervals for associations between the risk of composite cardiovascular disease, coronary heart disease, stroke, all cause mortality, and prediabetes. REVIEW METHODS: ) of 39-47 mmol/mol : (5.7-6.4%) according to ADA criteria or 42-47 mmol/mol (6.0-6.4%) according to the National Institute for Health and Care Excellence (NICE) guideline. The relative risks of all cause mortality and cardiovascular events were calculated and reported with 95% confidence intervals.