reviewCNS Neuroscience & TherapeuticsNov 22, 2016BRONZE OA

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

MGMojtaba GolpichEAElham AminiZMZahurin MohamedRARaymond Azman AliNMNorlinah Mohamed Ibrahim

University Kebangsaan Malaysia Medical Centre · University of Malaya · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and characterized by the progressive degeneration of the function and structure of the central nervous system (CNS) for reasons that are not yet understood. Neurodegeneration is the umbrella term for the progressive death of nerve cells and loss of brain tissue. Because of their high energy requirements, neurons are especially vulnerable to injury and death from dysfunctional mitochondria. Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy. Several lines of pathological and physiological evidence reveal that impaired mitochondrial function and dynamics play crucial roles in…

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536
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100%
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Authors

6

Topics & keywords

Topics
Keywords
  • Neurodegeneration
  • Mitochondrion
  • Amyotrophic lateral sclerosis
  • Mitochondrial biogenesis
  • Neuroscience
  • Pathogenesis
  • Disease
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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