Gut microbiota induce IGF-1 and promote bone formation and growth
Brigham and Women's Hospital · Harvard University · +3 more institutions
Abstract
Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has exploded recently. However, the effects of gut microbiota on skeletal growth and homeostasis have only recently begun to be explored. Here, we report that colonization of sexually mature germ-free (GF) mice with conventional specific pathogen-free (SPF) gut microbiota increases both bone formation and resorption, with the net effect of colonization varying with the duration of colonization. Although colonization of adult mice acutely reduces bone mass, in long-term colonized mice, an increase in bone formation and growth plate activity predominates, resulting in equalization of bone mass and increased longitudinal and radial…
Citation impact
- FWCI
- 22.46
- Percentile
- 100%
- References
- 66
Authors
9Topics & keywords
- Dysbiosis
- Bone resorption
- Osteoporosis
- Microbiome
- Gut flora
- Bone remodeling
- Bone health
- Growth factor
Funding
- DRDamon Runyon Cancer Research FoundationAward: DRG-2205-14
- CACrohn's and Colitis Foundation of America
- RRRheumatology Research Foundation
- CACrohn's and Colitis Foundation
- NINational Institutes of HealthAwards: R01 AG046257, 5-P40-OD010995, P40-OD010995, K08 AR062590, P30-DK034987, DK034987, R01 CA154426
- UOUniversity of North Carolina at Chapel HillAward: DK034987
- NINational Institute on AgingAward: AG046257
- NONIH Office of the DirectorAward: 5-P40-OD010995
- NCNational Cancer InstituteAward: CA154426
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAward: P30-DK034987
- NINational Institute of Arthritis and Musculoskeletal and Skin DiseasesAward: AR062590