A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome
Ludwig Cancer Research · University of California, San Diego · +11 more institutions
Abstract
The three-dimensional configuration of DNA is integral to all nuclear processes in eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide chromosome conformation capture studies have uncovered features of chromatin organization in cultured cells, but genome architecture in human tissues has yet to be explored. Here, we report the most comprehensive survey to date of chromatin organization in human tissues. Through integrative analysis of chromatin contact maps in 21 primary human tissues and cell types, we find topologically associating domains highly conserved in different tissues. We also discover genomic regions that exhibit unusually high levels of local chromatin…
Citation impact
- FWCI
- 50.13
- Percentile
- 100%
- References
- 52
Authors
11- ADAnthony D. Schmitt
Ludwig Cancer Research, University of California, San Diego
- MHMing HuCorresponding
New York University
- IJInkyung Jung
Ludwig Cancer Research
- ZXZheng Xu
University of North Carolina at Chapel Hill, University of Nebraska–Lincoln
- YQYunjiang Qiu
University of California, San Diego, Ludwig Cancer Research
Topics & keywords
- Chromatin
- CTCF
- Chromosome conformation capture
- ChIA-PET
- Genome
- Biology
- Cohesin
- Scaffold/matrix attachment region