Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota
Capital Medical University · Beijing Children’s Hospital
Abstract
Elucidating the mechanisms by which short chain fatty acids (SCFA) reduce body weight may assist in the development of an effective weight control strategy. Dietary supplementation of acetate, propionate, butyrate or their admixture was shown to significantly inhibit the body weight gain induced by high-fat diet feeding. Supplementation of SCFAs caused significant changes in the expressions of G-protein coupled receptor 43 (GPR43) and GPR41 characterized by increases in the adipose tissue and reductions in the colon. Additionally, they influenced the bacterial community structure in feces, with a reduction in the proportion of Firmicutes and an increase in the proportion of Bacteroidetes. The effects of…
Citation impact
- FWCI
- 21.06
- Percentile
- 100%
- References
- 69
Authors
6- YLYuanyuan LuCorresponding
Capital Medical University, Beijing Children’s Hospital
- CFChaonan Fan
Capital Medical University, Beijing Children’s Hospital
- PLPing Li
Capital Medical University, Beijing Children’s Hospital
- YLYanfei Lu
Capital Medical University, Beijing Children’s Hospital
- XCXuelian Chang
Capital Medical University, Beijing Children’s Hospital
Topics & keywords
- Gut flora
- Adipose tissue
- Butyrate
- Propionate
- Firmicutes
- Endocrinology
- Adipogenesis
- Triglyceride