articleScienceDec 1, 2016GREEN OA

Reactivation of latent working memories with transcranial magnetic stimulation

University of Notre Dame · University of Wisconsin–Madison · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

The ability to hold information in working memory is fundamental for cognition. Contrary to the long-standing view that working memory depends on sustained, elevated activity, we present evidence suggesting that humans can hold information in working memory via "activity-silent" synaptic mechanisms. Using multivariate pattern analyses to decode brain activity patterns, we found that the active representation of an item in working memory drops to baseline when attention shifts away. A targeted pulse of transcranial magnetic stimulation produced a brief reemergence of the item in concurrently measured brain activity. This reactivation effect occurred and influenced memory performance only when the item was…

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