A comprehensive excitatory input map of the striatum reveals novel functional organization

The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse functions. Although the striatum is thought to consist of sensorimotor, associative and limbic domains, their precise demarcations and whether additional functional subdivisions exist remain unclear. How striatal inputs are differentially segregated into each domain is also poorly understood. This study presents a comprehensive map of the excitatory inputs to the mouse striatum. The input patterns reveal boundaries between the known striatal domains. The most posterior striatum likely represents the 4th functional subdivision, and the dorsomedial striatum integrates highly heterogeneous, multimodal inputs. The…

• NS
  National Science Foundation
• NI
  National Institute of Mental Health

  Award: DP2OD008425
• NI
  National Institute of Neurological Disorders and Stroke

  Awards: U01NS094247, R01NS081071